HB FUKUTOMI [ALPHA-126(H9)ASP-]VAL] - A NEW HEMOGLOBIN-VARIANT WITH HIGH OXYGEN-AFFINITY

被引：7
|
作者：
HIDAKA, K [1 ]
IUCHI, I [1 ]
KOBAYASHI, T [1 ]
KATOH, K [1 ]
YAGUCHI, K [1 ]
机构：
[1] KAWASAKI HOSP, KAWASAKI MED SCH,DEPT INTERNAL MED, OKAYAMA 700, JAPAN
来源：
HEMOGLOBIN | 1990年 / 14卷 / 05期
关键词：
D O I：
10.3109/03630269009005803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hb Fukutomi [alpha-126(H9)Asp-->Val], a new hemoglobin variant with a high affinity for oxygen (log P50 = 0.201 at pH 7.0, normal = 1.087) was detected in a Japanese male during a screening survey. The amino acid substitution is located in the alpha1beta1 contact of the tetramic molecule. Like other variants of the high oxygen affinity type Hb Fukutomi showed increased resistance to auto-oxidation. The tryptic peptide alpha-T-13, that usually forms part of the trypsin-resistant core of the alpha chain, was cleaved off by trypsin in the new variant and released into the soluble fraction.
引用
收藏
页码：499 / 509
页数：11
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