ANTIFERTILITY EFFECTS IN FEMALE RATS IMMUNIZED WITH HUMAN SEMINAL PLASMA INHIBIN

被引：0
|
作者：
HURKADLI, KS
VERNEKAR, VJ
SHETH, AR
机构：
[1] Institute for Research in Reproduction (ICMR) Jehangir, Parel Bombay, 400 012, Merwanji Street
来源：
CONTRACEPTION | 1993年 / 47卷 / 05期
关键词：
D O I：
10.1016/0010-7824(93)90101-C
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Adult female rats were actively immunized with sperm-coating protein (10.4 KDa) human seminal plasma inhibin (HSPI). Following 8 weeks of immunization at 2.5 ug and 5 ug doses of HSPI with Freund's complete adjuvant, antifertility effects were observed in 63% (5/8) and 88% (7/8) of animals, respectively. Estrous cycle was not affected in experimental group. Thus, the present study suggests the potential use of HSPI for immunocontraception in females.
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页码：491 / 498
页数：8
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