EFFECT OF ACUTE TRYPTOPHAN DEPLETION ON MOOD AND APPETITE IN HEALTHY FEMALE VOLUNTEERS

被引：39
|
作者：
OLDMAN, AD
WALSH, AES
SALKOVSKIS, P
LAVER, DA
COWEN, PJ
机构：
[1] UNIV OXFORD,DEPT PSYCHIAT,OXFORD OX4 4XN,ENGLAND
[2] LITTLEMORE HOSP,MRC,CLIN PHARMACOL UNIT,OXFORD OX4 4XN,ENGLAND
来源：
JOURNAL OF PSYCHOPHARMACOLOGY | 1994年 / 8卷 / 01期
关键词：
L-TRYPTOPHAN; APPETITE; HUNGER; MOOD; CALORIES; MACRONUTRIENT;
D O I：
10.1177/026988119400800102
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Twelve healthy female subjects received the following three drinks in a double-blind, semi-balanced, crossover design: (a) 50 g of amino acids without L-tryptophan (LTP); (b) 50 g of amino acid with LTP (balanced); (c) plain water. Compared to both the balanced amino acid mixture and plain water, the LTP drink significantly lowered plasma total and free tryptophan at 4.5 h. However, compared to the two control conditions, there was no effect of the LTP drink on subjective ratings of mood or hunger. Similarly, the LTP drink did not alter significantly either total calorie intake or the macronutrient content of a test meal 5 h after drink ingestion.
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页码：8 / 13
页数：6
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