GENE FOR THE CATALYTIC SUBUNIT OF MOUSE DNA-DEPENDENT PROTEIN-KINASE MAPS TO THE SCID LOCUS

被引：52
|
作者：
MILLER, RD
HOGG, J
OZAKI, JH
GELL, D
JACKSON, SP
RIBLET, R
机构：
[1] MED BIOL INST,LA JOLLA,CA 92037
[2] UNIV CAMBRIDGE,WELLCOME CANC RES CAMPAIGN INST,CAMBRIDGE CB2 1QR,ENGLAND
[3] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 1QR,ENGLAND
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 23期
基金：
英国惠康基金;
关键词：
D O I：
10.1073/pnas.92.23.10792
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus, We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel, We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
引用
收藏
页码：10792 / 10795
页数：4
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