EVIDENCE FOR L-DOPA SYSTEMS RESPONSIBLE FOR CARDIOVASCULAR CONTROL IN THE NUCLEUS-TRACTUS-SOLITARII OF THE RAT

被引：62
|
作者：
KUBO, T [1 ]
YUE, JL [1 ]
GOSHIMA, Y [1 ]
NAKAMURA, S [1 ]
MISU, Y [1 ]
机构：
[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHARMACOL, YOKOHAMA 236, JAPAN
来源：
NEUROSCIENCE LETTERS | 1992年 / 140卷 / 02期
关键词：
L-DOPA; D-DOPA; L-DOPA METHYL ESTER; COMPETITIVE L-DOPA ANTAGONIST; DOPAMINE; NORADRENALINE; NUCLEUS-TRACTUS-SOLITARII; BLOOD PRESSURE; RELEASE OF ENDOGENOUS DOPA; RAT;
D O I：
10.1016/0304-3940(92)90090-T
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microinjections of L-DOPA (10-100 ng) into the medial area of the nucleus tractus solitarii (NTS) led to dose-dependent decreases in arterial blood pressure and heart rate in rats treated with i.p. 3-hydroxybenzylhydrazine, a central inhibitor of DOPA decarboxylase, or similarly with intraventricular 6-hydroxydopamine. D-DOPA, dopamine or noradrenaline (100 ng) produced no effect. L-DOPA methyl ester (1-mu-g), a competitive antagonist for L-DOPA, microinjected into NTS. blocked the depressor and bradycardic responses to L-DOPA. High K+ (40 mM) released endogenous DOPA in a Ca2+-dependent manner from slices of the rat dorsomedial medulla including NTS. These results support the hypothesis that there exist systems Of L-DOPA itself responsible for cardiovascular regulation in NTS of rats. This regulatory action Of L-DOPA seems to be postsynaptic in nature.
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页码：153 / 156
页数：4
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