PROGNOSTIC VALUE OF HISTOPATHOLOGY IN EWINGS-SARCOMA - LONG-TERM FOLLOW-UP OF DISTAL EXTREMITY PRIMARY TUMORS

被引:0
|
作者
HARTMAN, KR
TRICHE, TJ
KINSELLA, TJ
MISER, JS
机构
[1] UNIV SO CALIF, CHILDRENS HOSP LOS ANGELES, DEPT PATHOL & LAB MED, 4650 SUNSET BLVD, LOS ANGELES, CA 90027 USA
[2] WALTER REED ARMY MED CTR, DIV PEDIAT HEMATOL ONCOL, WASHINGTON, DC 20307 USA
[3] UNIV WISCONSIN, CTR CLIN CANC, MADISON, WI 53706 USA
[4] MAYO CLIN & MAYO FDN, DEPT PEDIAT, ROCHESTER, MN 55905 USA
关键词
D O I
10.1002/1097-0142(19910101)67:1<163::AID-CNCR2820670128>3.0.CO;2-Y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The pathologic material from 56 patients diagnosed initially as Ewing's sarcoma of the distal extremity and treated on National Cancer Institute protocols between 1968 and 1984 was reviewed and correlated with clinical outcome. Histologically, the tumors were categorized, based on recent pathologic criteria, into three diagnostic groups: (1) typical Ewing's sarcoma, (2) atypical Ewing's sarcoma, and (3) other (predominantly peripheral neuroepithelioma [PN]). Thirty-two patients (57%) had typical Ewing's, 13 (23%) were atypical, and 11 (20%) were in the "other" diagnostic category (seven [13%] PN, two primitive rhabdomyosarcoma, one primitive sarcoma of bone, and one synovial cell sarcoma). No cases of metastatic neuroblastoma, osteosarcoma, or lymphoma were found. Forty-five patients had localized disease at diagnosis; 11 had metastases. Patients with typical Ewing's sarcoma were less likely to have metastatic disease at the time of diagnosis. Only two of 32 patients with typical Ewing's sarcoma had metastases compared with nine of 24 patients in the two other groups. The pattern of relapse was also different in these other groups compared with typical Ewing's patients; five patients developed lymp node metastases and two patients developed brain metastases. Although the presence of metastatic disease at diagnosis was a strong negative prognostic factor, our histologic grouping was independently prognostic of clinical outcome in patients with localized disease. Patients with typical osseous Ewing's sarcoma had an improved overall survival (P2 = 0.03) and patients with other tumors (neither typical nor atypical Ewing's sarcoma) had a poorer disease-free survival (P2 = 0.02). Since no generally accepted histopathologic prognostic criteria exist for Ewing's sarcoma, the potential value of our proposed classification should be evaluated in a larger retrospective and a prospective study.
引用
收藏
页码:163 / 171
页数:9
相关论文
共 50 条
  • [21] Pancreaticoduodenectomy for distal cholangiocarcinoma: surgical results, prognostic factors, and long-term follow-up
    Andrianello, Stefano
    Paiella, Salvatore
    Allegrini, Valentina
    Ramera, Marco
    Pulvirenti, Alessandra
    Malleo, Giuseppe
    Salvia, Roberto
    Bassi, Claudio
    LANGENBECKS ARCHIVES OF SURGERY, 2015, 400 (05) : 623 - 628
  • [22] Pancreaticoduodenectomy for distal cholangiocarcinoma: surgical results, prognostic factors, and long-term follow-up
    Stefano Andrianello
    Salvatore Paiella
    Valentina Allegrini
    Marco Ramera
    Alessandra Pulvirenti
    Giuseppe Malleo
    Roberto Salvia
    Claudio Bassi
    Langenbeck's Archives of Surgery, 2015, 400 : 623 - 628
  • [23] LONG-TERM SURVIVAL IN PATIENTS WITH EWINGS-SARCOMA RELAPSING AFTER COMPLETING THERAPY
    HAYES, FA
    THOMPSON, EI
    KUMAR, M
    HUSTU, HO
    MEDICAL AND PEDIATRIC ONCOLOGY, 1987, 15 (05): : 254 - 256
  • [24] EWINGS-SARCOMA OF THE LUMBAR SPINE - A CASE-REPORT OF LONG-TERM SURVIVAL
    RUSSIN, LA
    ROBINSON, MJ
    ENGLE, HA
    SONNI, A
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1982, (164) : 126 - 129
  • [25] Second primary tumors in laryngeal cancer: Results of long-term follow-up
    Narayana, A
    Vaughan, ATM
    Fisher, SG
    Reddy, SP
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (03): : 557 - 562
  • [26] Primary extremity sarcoma: What is the appropriate follow-up?
    Whooley, BP
    Gibbs, JF
    Mooney, MM
    McGrath, BE
    Kraybill, WG
    ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (01) : 9 - 14
  • [27] Primary Extremity Sarcoma: What Is the Appropriate Follow-Up?
    Brian P. Whooley
    John F. Gibbs
    Margaret M. Mooney
    Brian E. McGrath
    William G. Kraybill
    Annals of Surgical Oncology, 2000, 7 : 9 - 14
  • [28] Long-term follow-up of cartilaginous tumors of the larynx
    Thomé, R
    Thomé, DC
    De la Cortina, RAC
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2001, 124 (06) : 634 - 640
  • [29] Long-term Follow-up of Borderline Ovarian Tumors Clinical Outcome and Prognostic Factors
    Lazarou, Anastasia
    Fotopoulou, Christina
    Coumbos, Alexandra
    Sehouli, Jalid
    Vasiljeva, Jekaterina
    Braicu, Ioana
    Burger, Heinz
    Kuehn, Wolfgang
    ANTICANCER RESEARCH, 2014, 34 (11) : 6725 - 6730
  • [30] EXTRAGONADAL GERM-CELL TUMORS - PROGNOSTIC FACTORS AND LONG-TERM FOLLOW-UP
    APARICIO, J
    MONTALAR, J
    MUNARRIZ, EB
    REYNES, G
    GOMEZCODINA, J
    PASTOR, M
    HERRANZ, C
    EUROPEAN UROLOGY, 1995, 28 (01) : 19 - 24