One hundred and one patients with Panic Disorder/Agoraphobia and forty controls were assessed for DSM-III-R Axis II Disorders and for familial risks for Anxiety and Mood Disorders. Cluster C was the most represented in panic patients; Cluster B was also highly represented. The most common PD among patients were Histrionic, Dependent, and Avoidant. We also found significantly more first-degree relatives with Panic Disorder in the families of panic patients. The presence of PD in the proband did not influence the distribution of the risk for Panic Disorder in the families. The results may suggest that the individual liability to panic is more likely to depend on familial factors than on individual patterns of pathologic personality.