TUMOR-SUPPRESSOR-GENES - THEIR OCCURRENCE, SIGNIFICANCE AND FUNCTION

被引：0
|
作者：
SCHEURLEN, W
KRETH, HW
机构：
来源：
MONATSSCHRIFT KINDERHEILKUNDE | 1991年 / 139卷 / 10期
关键词：
TUMOR-SUPPRESSOR-GENES; RECESSIVE ONCOGENES; CHILDHOOD TUMOR; RETINOBLASTOMA; WILMS TUMOR;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Tumor-suppressor-genes werde detected by DNA-analysis of childhood tumors. A homocygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.
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页码：650 / 654
页数：5
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