THE EFFECT OF AMPHIPHILIC POLYMERS ON GROWTH OF BORDETELLA-PERTUSSIS AND PRODUCTION OF BORDETELLA-PERTUSSIS HEMAGGLUTININS

被引：2
|
作者：
NIKOLAJEWSKI, HE [1 ]
LIEPERT, H [1 ]
NIKOLAJEWSKI, G [1 ]
PFULLER, U [1 ]
SWIDSINSKI, S [1 ]
WETTIG, G [1 ]
机构：
[1] ACAD SCI GDR,ZENT INST PHYS CHEM,O-1199 BERLIN,GERMANY
来源：
BIOLOGICALS | 1990年 / 18卷 / 04期
关键词：
D O I：
10.1016/1045-1056(90)90034-W
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect, upon addition to a culture medium of amphiphilic polymers such as partly hydrolysed polyvinyl acetate (PVAc) or partly methylated cellulose (MeCel) on growth and production of haemagglutinins-the filamentous haemagglutinin (FHA) and the pertussis toxin (PT)-has been investigated. As a result, an increase of HA-titer and PT could be achieved. Besides these effects the addition of the amphiphilic polymers stimulated growth of B. pertussis. The above results are comparable to, or even better than, those obtained by addition of Heptakis (2,6-0-dimethyl) β-cyclodextrin (Me-β-CD) or polyvinyul alcohols (PVA) which have already been described as compounds to enhance growth and yield of haemagglutinins. © 1990.
引用
收藏
页码：305 / 308
页数：4
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