Physiological Activity Of Platelets In Vivo During Aging Against The Background Of Physical Exertion

The aging process inevitably affects all the systems of the body. This complex extinction of the body's functions, leading to its death. The aging changes also affect blood parameters in the mammalian organism, including influencing platelet hemostasis, sometimes causing thrombophilic changes. These changes are very significant in the pathogenesis of virtually all cardiovascular diseases, which often occur in a person with age. Due to the fact that membranes of activated platelets provide hemostasis processes, it becomes clear the importance of weakening the disaggregation mechanisms, which can easily be disrupted. In this regard, it is very important to carry out experimental work on the study of their various aspects. Very dosage physical exercises are very accessible and have no side effects. As it is explained, they can often attenuate platelet activity especially in cardiovascular pathology. This helps reduce the risk of developing thrombosis, which severely limit life expectancy. The aim of the work is to elucidate in the model of aging rats the possibility of inhibition of platelet activity in vivo with the help of regular physical exertion. The study included 26 healthy male rats 12 months. Age, experienced during the year, daily physical activity. The control is represented by 91 healthy male colors: 30 animals of 12 months of age, 32 rats of 18 months and 29 animals of 24 months of age. Biochemical, hematological and statistical methods of investigation has been applied. In control rats, as the age increases, there is a gradual increase in the activity of thrombocytes. Regular daily exercise in rats between 12 and 24 months of life provided stabilization of intravascular activity of platelets, inhibiting its age-related enhancement.