Fatal Cryptococcus gattii genotype AFLP5 infection in an immunocompetent Cuban patient

被引：15
|
作者：
Illnait-Zaragozi, Maria T. [1 ]
Ortega-Gonzalez, Lilia M. [2 ]
Hagen, Ferry [3 ]
Martinez-Machin, Gerardo F. [1 ]
Meis, Jacques F. [3 ,4 ]
机构：
[1] Trop Med Inst Pedro Komi, Dept Microbiol, Havana, Cuba
[2] Trop Med Inst Pedro Komi, Intens Care Unit, Havana, Cuba
[3] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, POB 9015, NL-6500 GS Nijmegen, Netherlands
[4] Radhoud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
来源：
MEDICAL MYCOLOGY CASE REPORTS | 2013年 / 2卷
关键词：
Cryptococcal meningitis; C; grata; AFLP5; Imported mycoses; Treatment;
D O I：
10.1016/j.mmcr.2013.02.001
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We describe the first clinical case of cryptococcosis due C. gattii in a Cuban immunocompetent patient who had a traveling history two years before to Central America. Molecular characterization of the isolate showed it to be genotype AFLP5 of which MLST sequences clustered with clinical and environmental strains from Colombia. The patient died one year after the diagnosis despite a prolonged treatment with (liposomal) amphotericin B, fluconazole, voriconazole and gamma interferon. (C) 2013 International Society for Human and Animal Mycology. Published by Elsevier B.V
引用
收藏
页码：48 / 51
页数：4
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