THE B-TYPE CYCLIN KINASE INHIBITOR P40(SIC1) CONTROLS THE G1 TO S TRANSITION IN SACCHAROMYCES-CEREVISIAE

被引：786

作者：

SCHWOB, E ^{[1
]}

BOHM, T ^{[1
]}

MENDENHALL, MD ^{[1
]}

NASMYTH, K ^{[1
]}

机构：

[1] UNIV KENTUCKY,LUCILLE P MARKEY CANC CTR,DEPT BIOCHEM,LEXINGTON,KY 40536

来源：

CELL | 1994年 / 79卷 / 02期

关键词：

D O I：

10.1016/0092-8674(94)90193-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When yeast cells reach a critical size, they initiate bud formation, spindle pole body duplication, and DNA replication almost simultaneously. All three events depend on activation of Cdc28 protein kinase by the G1 cyclins Cln1, -2, and -3. We show that DNA replication also requires activation of Cdc28 by B-type (Clb) cyclins. A sextuple clb1-6 mutant arrests as multibudded G1 cells that resemble cells lacking the Cdc34 ubiquitin-conjugating enzyme. cdc34 mutants cannot enter S phase because they fail to destroy p40(SIC1), which is a potent inhibitor of Clb but not Cln forms of the Cdc28 kinase. In wild-type cells, p40(SIC1) protein appears at the end of mitosis and disappears shortly before S phase. Proteolysis of a cyclin-specific inhibitor of Cdc28 is therefore an essential aspect of the G1 to S phase transition.

引用

页码：233 / 244

页数：12

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