GABA(B) RECEPTOR ANTAGONIST CGP-35348 SHORTENS TRANSCALLOSAL RESPONSE LATENCY OF PYRAMIDAL TRACT NEURONS

被引：6

作者：

CHOWDHURY, SA

KAWASHIMA, T

KONISHI, T

NIWA, M

MATSUNAMI, K

机构：

[1] GIFU UNIV,SCH MED,INST EQUILIBRIUM RES,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,DEPT PHARMACOL,GIFU 500,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 285卷 / 01期

关键词：

GABA(B) RECEPTOR ANTAGONIST; CGP; 35348; PYRAMIDAL TRACT NEURON; TRANSCALLOSAL RESPONSE; CAT; MOTOR CORTEX;

D O I：

10.1016/0014-2999(95)00483-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a specific GABA(B) receptor antagonist, p-(3-aminopropyl)-p-diethoxymethyl-phosphonic acid (CGP 35348), on pyramidal tract neuron responses to transcallosal stimulation were investigated in the cat motor cortex in vivo. Iontophoretic application of CGP 35348 significantly increased the number of spikes from 10.3 +/- 4.4 (control; n = 27; mean +/- S.D.) to 16.7 +/- 7.2 (CGP 35348) for 20 transcallosal stimulation trials, while the latency of neuronal activity was significantly shortened from 4.4 +/- 2.1 ms (control; n = 27; mean +/- S.D.) to 3.8 +/- 1.7 ms (CGP 35348). Tn conclusion, CGP 35348 facilitated transcallosal synaptic transmission between pyramidal tract neurons by removal of GABA(B) inhibition.

引用

页码：99 / 102

页数：4

共 34 条

[21] Comparative in vivo and in vitro studies with the potent GABA(B) receptor antagonist, CGP 56999A
Badran, S
Schmutz, M
Olpe, HR
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 333 (2-3) : 135 - 142
[22] THE SELECTIVE GABA(B) ANTAGONIST CGP35348 INHIBITS SPIKE-WAVE BURSTING IN THE CHOLESTEROL-SYNTHESIS RAT ABSENCE EPILEPSY MODEL
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FISHER, RS
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[23] MODIFICATION OF SYNAPTIC RESPONSES OF ENTORHINAL CORTICAL-NEURONS BY A NEW GABA(B) ANTAGONIST, CGP-55845
DHILLON, A
JONES, RSG
BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 : U5 - U5
[24] Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats
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[25] GABA-B receptor antagonist, CGP51176, produces antidepressant-like effects in rodents
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Nowak, Gabriel
Partyka, Anna
Wieronska, Joanna
Branski, Piotr
Papp, Mariusz
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[26] The GABA(B) receptor antagonist CGP 36 742 and the nootropic oxiracetam facilitate the formation of long-term memory
Mondadori, C
Mobius, HJ
Borkowski, J
BEHAVIOURAL BRAIN RESEARCH, 1996, 77 (1-2) : 223 - 225
[27] CGP 36 742, an orally active GABA(B) receptor antagonist, facilitates memory in a social recognition test in rats
Mondadori, C
Moebius, HJ
Zingg, M
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[28] GABA-A RECEPTOR ANTAGONIST BICUCULLINE ALTERS RESPONSE PROPERTIES OF POSTEROVENTRAL COCHLEAR NUCLEUS NEURONS
PALOMBI, PS
CASPARY, DM
JOURNAL OF NEUROPHYSIOLOGY, 1992, 67 (03) : 738 - 746
[29] REPEATED ADMINISTRATION OF DESIPRAMINE AND A GABA(B) RECEPTOR ANTAGONIST, CGP-36742, DISCRETELY UP-REGULATES GABA(B) RECEPTOR-BINDING SITES IN RAT FRONTAL-CORTEX
PRATT, GD
BOWERY, NG
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (02) : 724 - 735
[30] The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats
Nakagawa, Y
Takashima, T
BRAIN RESEARCH, 1997, 766 (1-2) : 101 - 106

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