ACTIVATION OF METABOTROPIC RECEPTORS HAS A NEUROPROTECTIVE EFFECT IN A RODENT MODEL OF FOCAL ISCHEMIA

被引：90
|
作者：
CHIAMULERA, C
ALBERTINI, P
VALERIO, E
REGGIANI, A
机构：
[1] Glaxo Research Laboratories, Verona
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 02期
关键词：
EXCITATORY AMINO ACIDS; METABOTROPIC RECEPTORS; CEREBRAL ISCHEMIA;
D O I：
10.1016/0014-2999(92)90382-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The role of the glutamate 'metabotropic' receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral artery occlusion (MCAO), which causes cerebral infarct. Seven days after MCAO, the mean infarct volume value of the t-ACPD-treated group (mean +/- S.E. = 4.57 +/- 0.73 mm3) was significantly reduced, by 34.3%, compared to the vehicle-treated group (mean +/- S.E. = 6.95 +/- 0.59 mm3, P < 0.01). This suggests that metabotropic receptor activation in the adult brain reduces excitotoxicity.
引用
收藏
页码：335 / 336
页数：2
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