A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta-analysis

被引:5
|
作者
Wu, Jing [1 ]
Guan, Xuan [2 ]
Zhang, Kui [3 ]
Li, Ya-Ting [1 ]
Bai, Peng [3 ]
Wu, Jin [1 ]
机构
[1] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Forens Biol, 17 South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Chengdu Med Coll, Sch Basic Med Sci, Chengdu 610500, Sichuan, Peoples R China
[3] Sichuan Univ, West China Univ Hosp 2, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
关键词
polymorphism; matrix metalloproteinase; cancer risk; meta-analysis;
D O I
10.3892/br.2013.131
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This meta-analysis was conducted to evaluate the effect of the matrix metalloproteinase 7 (MMP7)-181A/G polymorphism on cancer risk. Twenty-seven case-control studies were identified via a literature search through PubMed, Web of Science and China National Knowledge Infrastructure databases. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were applied to assess the strength of the association between MMP7-181A/G polymorphism and cancer risk. The 27 studies were further assessed according to Hardy-Weinberg equilibrium (HWE) and Hardy-Weinberg disequilibrium (HWD), with 24 case-control studies found to be under HWE. A significant association was observed between MMP7-181A/G polymorphism and increased cancer risk (cervical and other types of cancer) in Asian, but not in European populations.
引用
收藏
页码:792 / 796
页数:5
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