PHENYTOIN-INDUCED RESISTANCE TO VECURONIUM

被引：29
|
作者：
PLATT, PR [1 ]
THACKRAY, NM [1 ]
机构：
[1] SIR CHARLES GAIRDNER HOSP,DEPT ANAESTHESIA,PERTH,WA,AUSTRALIA
来源：
ANAESTHESIA AND INTENSIVE CARE | 1993年 / 21卷 / 02期
关键词：
NEUROMUSCULAR RELAXANTS; SUCCINYLCHOLINE; VECURONIUM; ANTICONVULSANTS; PHENYTOIN; COMPLICATIONS; DRUG INTERACTION; HYPERKALEMIA;
D O I：
10.1177/0310057X9302100209
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Chronic phenytoin therapy causes resistance to some nondepolarising muscle relaxants. We have confirmed that this resistance is seen with vecuronium and suggest that at least a week of phenytoin therapy is required for a significant effect to develop. The mechanism of this resistance is not known. We have shown that an exaggerated rise in serum potassium after succinylcholine does not occur in patients with demonstrated resistance to vecuronium from chronic phenytoin therapy. This would suggest that significant extrajunctional acetylcholine receptor proliferation is an unlikely mechanism.
引用
收藏
页码：185 / 191
页数：7
相关论文
共 50 条
  • [21] PHENYTOIN-INDUCED NEPHROTIC SYNDROME
    ORLANDINI, G
    GARINI, G
    NEPHRON, 1989, 52 (01): : 109 - 109
  • [22] PHENYTOIN-INDUCED NOCTURNAL ENURESIS
    HILDEBRANDT, WK
    DRUG INTELLIGENCE & CLINICAL PHARMACY, 1977, 11 (08): : 492 - 492
  • [23] Phenytoin-Induced Gingival Enlargement
    Bakshi, Satvinder Singh
    ERCIYES MEDICAL JOURNAL, 2019, 41 (02) : 220 - 220
  • [24] PHENYTOIN-INDUCED CEREBELLAR DEGENERATION
    KOLLER, WC
    GLATT, SL
    FOX, JH
    ANNALS OF NEUROLOGY, 1980, 8 (02) : 203 - 204
  • [25] Phenytoin-induced Autoimmune Hepatitis
    Jhun, Hye Yeon
    Frenette, Catherine
    Schwartz, Mary
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 : S403 - S404
  • [26] Phenytoin-induced verrucous eruption
    Kayal, JD
    Ling, M
    CUTIS, 1998, 61 (02): : 101 - 102
  • [27] Phenytoin-induced gingival overgrowth
    Karn, Mitesh
    Sah, Ranjan
    Sapkota, Shabal
    CLEVELAND CLINIC JOURNAL OF MEDICINE, 2022, 89 (09) : 488 - 489
  • [28] PHENYTOIN-INDUCED INTERSTITIAL NEPHRITIS
    HOFFMAN, EW
    SOUTHERN MEDICAL JOURNAL, 1981, 74 (09) : 1160 - 1161
  • [29] PHENYTOIN-INDUCED METHADONE WITHDRAWAL
    TONG, TG
    POND, SM
    KREEK, MJ
    JAFFERY, NF
    BENOWITZ, NL
    ANNALS OF INTERNAL MEDICINE, 1981, 94 (03) : 349 - 351
  • [30] PHENYTOIN-INDUCED HYPERSENSITIVITY REACTIONS
    PROSSER, TR
    LANDER, RD
    CLINICAL PHARMACY, 1987, 6 (09): : 728 - 734
12345