CONSTRUCTION OF A PHYSICAL MAP ON MOUSE AND HUMAN CHROMOSOME-1 - COMPARISON OF 13-MB OF MOUSE AND 11-MB OF HUMAN DNA

被引：50

作者：

OAKEY, RJ

WATSON, ML

SELDIN, MF

机构：

[1] DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA

[2] DUKE UNIV, MED CTR, DEPT MICROBIOL & IMMUNOL, DURHAM, NC 27710 USA

来源：

HUMAN MOLECULAR GENETICS | 1992年 / 1卷 / 08期

关键词：

D O I：

10.1093/hmg/1.8.613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long range restriction site maps of 13 Mb of mouse chromosome 1 and 11 Mb of human chromosome 1 were constructed using a framework provided by a detailed mouse genetic map. Where an unambiguous gene order could be determined in both species (14 genes), the human and mouse orders were identical. In addition, the distances between markers in the mouse and human were similar except for one region of the conserved linkage group where we could detect a larger distance in the mouse compared to the human. These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci.

引用

页码：613 / 620

页数：8

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