EFFECT OF POLYGLUTAMYLATION OF 5,10-METHYLENETETRAHYDROFOLATE ON THE BINDING OF 5-FLUORO-2'-DEOXYURIDYLATE TO THYMIDYLATE SYNTHASE PURIFIED FROM A HUMAN-COLON ADENOCARCINOMA XENOGRAFT

被引：68

作者：

RADPARVAR, S ^{[1
]}

HOUGHTON, PJ ^{[1
]}

HOUGHTON, JA ^{[1
]}

机构：

[1] ST JUDE CHILDRENS RES HOSP,DEPT BIOCHEM & CLIN PHARMACOL,DEV THERAPEUT LABS,332 N LAUDERDALE,MEMPHIS,TN 38101

来源：

BIOCHEMICAL PHARMACOLOGY | 1989年 / 38卷 / 02期

关键词：

D O I：

10.1016/0006-2952(89)90046-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：335 / 342

页数：8

共 46 条

[41] Genetic complementation and resistance to 5-fluoro-2′-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase
Zapf, JW
Zhao, PS
Steadman, DJ
Berger, SH
BIOCHEMICAL PHARMACOLOGY, 1999, 58 (06) : 973 - 981
[42] HIGHLY SELECTIVE DRUG-COMBINATIONS FOR HUMAN-COLON CANCER-CELLS RESISTANT INVITRO TO 5-FLUORO-2'-DEOXYURIDINE
SOBRERO, AF
HANDSCHUMACHER, RE
BERTINO, JR
CANCER RESEARCH, 1985, 45 (07) : 3161 - 3163
[43] MODULATION OF 5-FLUORO-2'-DEOXYURIDINE RESPONSE BY FOLINIC ACID IN HUMAN COLONIC TUMOR-CELL LINES - THE ROLE OF THYMIDYLATE SYNTHASE
DAVIS, ST
BERGER, SH
MOLECULAR PHARMACOLOGY, 1989, 35 (04) : 422 - 427
[44] Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells
Tong, YZ
Liu-Chen, XY
Ercikan-Abali, EA
Capiaux, GM
Zhao, SC
Banerjee, D
Bertino, JR
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (19) : 11611 - 11618
[45] A NATURALLY-OCCURRING TYROSINE TO HISTIDINE REPLACEMENT AT RESIDUE-33 OF HUMAN THYMIDYLATE SYNTHASE CONFERS RESISTANCE TO 5-FLUORO-2'-DEOXYURIDINE IN MAMMALIAN AND BACTERIAL-CELLS
BARBOUR, KW
HOGANSON, DK
BERGER, SH
BERGER, FG
MOLECULAR PHARMACOLOGY, 1992, 42 (02) : 242 - 248
[46] Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis
Zeng, Q-Y
Wang, Y-K
Xiao, Z-Y
Chen, S-B
ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (08) : 1193 - 1194

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