EFFECT OF POLYGLUTAMYLATION OF 5,10-METHYLENETETRAHYDROFOLATE ON THE BINDING OF 5-FLUORO-2'-DEOXYURIDYLATE TO THYMIDYLATE SYNTHASE PURIFIED FROM A HUMAN-COLON ADENOCARCINOMA XENOGRAFT

被引：68

作者：

RADPARVAR, S ^{[1
]}

HOUGHTON, PJ ^{[1
]}

HOUGHTON, JA ^{[1
]}

机构：

[1] ST JUDE CHILDRENS RES HOSP,DEPT BIOCHEM & CLIN PHARMACOL,DEV THERAPEUT LABS,332 N LAUDERDALE,MEMPHIS,TN 38101

来源：

BIOCHEMICAL PHARMACOLOGY | 1989年 / 38卷 / 02期

关键词：

D O I：

10.1016/0006-2952(89)90046-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：335 / 342

页数：8

共 46 条

[1] EFFECT OF 5,10-METHYLENETETRAHYDROFOLATE ON DISSOCIATION OF 5-FLUORO-2'-DEOXYURIDYLATE FROM THYMIDYLATE SYNTHETASE - EVIDENCE FOR AN ORDERED MECHANISM
DANENBERG, PV
DANENBERG, KD
BIOCHEMISTRY, 1978, 17 (19) : 4018 - 4024
[2] THYMIDYLATE SYNTHETASE - STUDIES ON PEPTIDE CONTAINING COVALENTLY BOUND 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE
POGOLOTTI, AL
IVANETICH, KM
SOMMER, H
SANTI, DV
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 70 (03) : 972 - 978
[3] BIPHASIC BINDING OF 5-FLUORO-2'-DEOXYURIDYLATE TO HUMAN THYMIDYLATE SYNTHASE
REILLY, RT
BARBOUR, KW
DUNLAP, RB
BERGER, FG
MOLECULAR PHARMACOLOGY, 1995, 48 (01) : 72 - 79
[4] SECONDARY ALPHA-HYDROGEN ISOTOPE EFFECTS ON THE INTERACTION OF 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE WITH THYMIDYLATE SYNTHETASE
BRUICE, TW
SANTI, DV
BIOCHEMISTRY, 1982, 21 (26) : 6703 - 6709
[5] RELATIONSHIP BETWEEN 5-FLUORO-2'-DEOXYURIDYLATE, 2'-DEOXYURIDYLATE, AND THYMIDYLATE SYNTHASE ACTIVITY SUBSEQUENT TO 5-FLUOROURACIL ADMINSTRATION, IN XENOGRAFTS OF HUMAN-COLON ADENOCARCINOMAS
HOUGHTON, JA
WEISS, KD
WILLIAMS, LG
TORRANCE, PM
HOUGHTON, PJ
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (08) : 1351 - 1358
[6] STEREOCHEMICAL MECHANISM OF ACTION FOR THYMIDYLATE SYNTHASE BASED ON THE X-RAY STRUCTURE OF THE COVALENT INHIBITORY TERNARY COMPLEX WITH 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE
MATTHEWS, DA
VILLAFRANCA, JE
JANSON, CA
SMITH, WW
WELSH, K
FREER, S
JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (04) : 937 - 948
[7] EVIDENCE FROM CHEMICAL DEGRADATION STUDIES FOR A COVALENT BOND FROM 5-FLUORO-2'-DEOXYURIDYLATE TO N-5 OF TETRAHYDROFOLATE IN THE TERNARY COMPLEX OF THYMIDYLATE SYNTHETASE-5-FLUORO-2'-DEOXYURIDYLATE-5,10-METHYLENETETRAHYDROFOLATE
PELLINO, AM
DANENBERG, PV
JOURNAL OF BIOLOGICAL CHEMISTRY, 1985, 260 (20) : 996 - 1000
[8] THYMIDYLATE SYNTHASES ISOLATED FROM HUMAN-COLON TUMORS HAVE VARIED AFFINITY TOWARDS 5-FLUORO-2'-DEOXYURIDYLATE
BAPAT, AR
DANENBERG, PV
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 299 - 299
[9] EFFECT OF RANEY-NICKEL ON COVALENT THYMIDYLATE SYNTHETASE-5-FLUORO-2'-DEOXYURIDYLATE-5,10-METHYLENETETRAHYDROFOLATE COMPLEX
DANENBERG, PV
HEIDELBERGER, C
BIOCHEMISTRY, 1976, 15 (06) : 1331 - 1337
[10] INTERACTION OF PURIFIED HUMAN THYMIDYLATE SYNTHETASE (TSASE) WITH 5-FLUORO-2'-DEOXYURIDYLATE (FDUMP)
LOCKSHIN, A
DANENBERG, PV
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1979, 20 (MAR): : 83 - 83

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