MULTIPLE-COLUMN SOLID-PHASE GLYCOPEPTIDE SYNTHESIS

被引：65
|
作者：
PETERS, S [1 ]
BIELFELDT, T [1 ]
MELDAL, M [1 ]
BOCK, K [1 ]
PAULSEN, H [1 ]
机构：
[1] CARLSBERG LAB,DEPT CHEM,DK-2500 COPENHAGEN,DENMARK
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 09期
关键词：
D O I：
10.1039/p19920001163
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of the two new building blocks N(alpha)-Fmoc-Ser(Ac3-alpha-D-GalpNAc)-OPfp 6 and N(alpha)-Fmoc-Thr(Ac3-alpha-D-GalpNAc)-OPfp 7 and their application in a simultaneous multiple-column solid-phase synthesis of 40 different O-glycopeptides from human intestinal mucin and porcine submaxillary gland mucin are described. All glycopeptides were obtained in excellent purity and were characterised by 1D- and 2D-H-1 NMR spectroscopy and amino acid analyses.
引用
收藏
页码：1163 / 1171
页数：9
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