EFFECT OF CISPLATIN ADMINISTRATION ON THE ELECTROCHEMICAL COMPOSITION OF ENDOLYMPH IN THE RAT COCHLEA

被引：14
|
作者：
LAURELL, G [1 ]
TEIXEIRA, M [1 ]
STERKERS, O [1 ]
FERRARY, E [1 ]
机构：
[1] UNIV PARIS 07,FAC XAVIER BICHAT,DEPT PHYSIOL,INSERM,U251,F-75018 PARIS,FRANCE
来源：
HEARING RESEARCH | 1995年 / 87卷 / 1-2期
关键词：
INNER EAR FLUIDS; LD50; ENDOCOCHLEAR POTENTIAL;
D O I：
10.1016/0378-5955(95)00074-E
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
The effect of cisplatin on the electrochemical composition of the cochlear endolymph was studied in Long-Evens rats three days after a single intraperitoneal injection (8 mg/kg b.w.). A dose 2/3 of LD50 induced a decrease of the endolymphatic concentration of potassium whereas the endocochlear potential was unaffected. The discrepancy between these two findings indicated that cisplatin did not alter the mechanisms involved in the genesis of the endocochlear potential but modified the passive K transport into endolymph.
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页码：16 / 20
页数：5
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