PULSE-RADIOLYSIS STUDIES ON THE OXIDATION OF OH(CENTER-DOT)RADICAL-DAMAGED DNA BY NITROQUINOLINES IN AQUEOUS-SOLUTION

被引:2
|
作者
ANDERSON, RF
DENNY, WA
WILSON, WR
PATEL, KB
机构
[1] UNIV AUCKLAND, CANC RES LAB, AUCKLAND, NEW ZEALAND
[2] UNIV AUCKLAND, CANC RES LAB, AUCKLAND, NEW ZEALAND
[3] MT VERNON HOSP, CANC RES CAMPAIGN, GRAY LAB, NORTHWOOD HA6 2JR, MIDDX, ENGLAND
来源
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS | 1995年 / 91卷 / 14期
关键词
D O I
10.1039/ft9959102115
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The reactions of nitroquinolines with radical sites on DNA, formed by OH. radical attack in aqueous solution, have been studied. It is found that the small concentrations of compound, unbound to DNA, oxidise the essentially immobile DNA radicals with diffusion-controlled rate constants of ca. 5 x 10(9) dm(3) mol(-1) s(-1) to form absorbing radical anions. Oxidation of the radical sites by the proportion of the compounds bound to DNA does not occur, except to a small extent in the case of the 6-nitro regioisomer. Calculations based on the measured intrinsic association constant and migration rate along DNA of the 6-nitro regioisomer yield a jump time between neighbouring sites on the DNA of 2.76 ns. Competition studies between such compounds which bind to DNA and xenobiotica for OH. radical-damaged sites on DNA is illustrated by studies with three thiol compounds which yield second-order rate constants for repair of the DNA radicals, through H-atom donation; glutathione, 1.2 x 10(6) dm(3) mol(-1) s(-1), cysteine, 6 x 10(6) dm(3) mol(-1) s(-1) and cysteamine, 1.6 x 10(8) dm(3) mol(-1) s(-1).
引用
收藏
页码:2115 / 2120
页数:6
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