FUNCTIONAL-SIGNIFICANCE OF ANGIOTENSIN RECEPTORS IN HUMAN MYOCARDIUM - SIGNIFICANT DIFFERENCES BETWEEN ATRIAL AND VENTRICULAR MYOCARDIUM

被引：19

作者：

HOLUBARSCH, C ^{[1
]}

SCHMIDTSCHWEDA, S ^{[1
]}

KNORR, A ^{[1
]}

DUIS, J ^{[1
]}

PIESKE, B ^{[1
]}

RUF, T ^{[1
]}

FASOL, R ^{[1
]}

HASENFUSS, G ^{[1
]}

JUST, H ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT CARDIOVASC SURG,D-79106 FREIBURG,GERMANY

来源：

EUROPEAN HEART JOURNAL | 1994年 / 15卷

关键词：

ANGIOTENSIN; MYOCARDIUM; INOTROPISM; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN RECEPTOR SUBTYPES;

D O I：

10.1093/eurheartj/15.suppl_D.88

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min(-1)). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the ATI receptor subtype but not the AT(2) receptor subtype.

引用

页码：88 / 91

页数：4

共 50 条

[41] Flecainide but not amiodarone induces diastolic dysfunction in atrial as well as ventricular human myocardium
Mayer, Christian
Djalinac, Natasa
Pagel, Christian
Pieske, Burkert
Bisping, Egbert Hubertus
WIENER KLINISCHE WOCHENSCHRIFT, 2019, 131 : 261 - 262
[42] FIBER TYPES AND MYOSIN TYPES IN HUMAN ATRIAL AND VENTRICULAR MYOCARDIUM - AN ANATOMICAL DESCRIPTION
BOUVAGNET, P
LEGER, J
PONS, F
DECHESNE, C
LEGER, JJ
CIRCULATION RESEARCH, 1984, 55 (06) : 794 - 804
[43] Mechanisms of atrial-fibrillation-induced ventricular dysfunction and recovery in the human left ventricular myocardium
Stengel, L.
Riedl, D.
Koertl, T.
Tirilomis, P.
Schramm, R.
Gummert, J.
Maier, L.
Streckfuss-Boemecke, K.
Pabel, S.
Sossalla, S.
EUROPEAN HEART JOURNAL, 2024, 45
[44] Mechanisms of atrial-fibrillation-induced ventricular dysfunction and recovery in the human left ventricular myocardium
Stengel, L.
Riedl, D.
Koertl, T.
Tirilomis, P.
Schramm, R.
Gummert, J.
Maier, L.
Streckfuss-Boemecke, K.
Pabel, S.
Sossalla, S.
EUROPEAN HEART JOURNAL, 2024, 45
[45] QUANTITATIVE AUTORADIOGRAPHIC DELINEATION OF BETA-ADRENERGIC RECEPTORS IN HUMAN VENTRICULAR MYOCARDIUM
MURPHREE, S
BAKER, J
SAFFITZ, J
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1987, 9 (02) : A133 - A133
[46] β2 Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium
Lowe, MD
Rowland, E
Brown, MJ
Grace, AA
HEART, 2001, 86 (01) : 45 - 51
[47] BETA-2 RECEPTORS ON MYOCARDIAL-CELLS IN HUMAN VENTRICULAR MYOCARDIUM
BRISTOW, MR
GINSBURG, R
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 57 (12): : F3 - F6
[48] Species comparison of adenosine A(1) receptors (A(1)R) in mammalian atrial and ventricular myocardium.
Kapicka, CL
Montamat, SC
Olson, RD
Mudumbi, RV
Vestal, RE
FASEB JOURNAL, 1996, 10 (03): : 2480 - 2480
[49] Gene expression of brain natriuretic peptide in isolated atrial and ventricular human myocardium -: Influence of angiotensin II and diastolic fiber length
Wiese, S
Breyer, T
Dragu, A
Wakili, R
Burkard, T
Schmidt-Schweda, S
Füchtbauer, EM
Dohrmann, U
Beyersdorf, F
Radicke, D
Holubarsch, CJF
CIRCULATION, 2000, 102 (25) : 3074 - 3079
[50] Sex differences in gene expression in response to ischemia in the human left ventricular myocardium
Stone, Gregory
Choi, Ashley
Oliva, Meritxell
Gorham, Joshua
Heydarpour, Mahyar
Seidman, Christine E.
Seidman, Jon G.
Aranki, Sary F.
Body, Simon C.
Carey, Vincent J.
Raby, Benjamin A.
Stranger, Barbara E.
Muehlschlegel, Jochen D.
HUMAN MOLECULAR GENETICS, 2019, 28 (10) : 1682 - 1693

← 1 2 3 4 5 →