COMPARATIVE INVITRO ACTIVITIES OF SPARFLOXACIN (CI-978, AT-4140) AND OTHER ANTIMICROBIAL AGENTS AGAINST STAPHYLOCOCCI, ENTEROCOCCI, AND RESPIRATORY-TRACT PATHOGENS

The in vitro activity of sparfloxacin (CI-978; AT-4140) was compared with those of other antimicrobial agents against isolates of staphylococci, enterococci, and various respiratory tract pathogens. Sparfloxacin was the most active drug tested against staphylococci (MIC for 90% of the strains tested [MIC90], 0.125 μg/ml) and enterococci (MIC90, 1.0 μg/ml). It was also active against Haemophilus influenzae (MIC90, ≤0.06 μg/ml), Moraxella (Branhamella) catarrhalis (MIC90, 0.125 μg/ml), Streptococcus pneumoniae (MIC90, 0.5 μg/ml), and Streptococcus pyogenes (MIC90, 1.0 μg/ml).