EFFECT OF TRICHOSANTHIN AND MOMORCHARINS ON ISOLATED RAT HEPATOCYTES

被引：3
|
作者：
NG, TB
LIU, WK
TSAO, SW
YEUNG, HW
机构：
[1] CHINESE UNIV HONG KONG,FAC MED,DEPT BIOCHEM,SHA TIN,HONG KONG
[2] CHINESE UNIV HONG KONG,DEPT ANAT,SHA TIN,HONG KONG
[3] CHINESE UNIV HONG KONG,CHINESE MED MAT RES CTR,SHA TIN,HONG KONG
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1994年 / 43卷 / 02期
关键词：
PLANT PROTEINS; HEPATOCYTE CULTURE; ENZYME ACTIVITIES; MORPHOLOGY;
D O I：
10.1016/0378-8741(94)90007-8
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
alpha-Momorcharin, beta-momorcharin and trichosanthin increased the secretion of glutamate-pyruvate transaminase, lactate dehydrogenase and isocitrate dehydrogenase by isolated rat hepatocytes into the culture medium. This hepatotoxic effect of the proteins appeared to be concentration-dependent. The plant proteins induced morphological changes in hepatocytes including increased formation of cytoplasmic blebs and a reduction of microvilli on plasma membrane.
引用
收藏
页码：81 / 87
页数：7
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