POSSIBLE EFFICACY OF TOLRESTAT (T), A NOVEL ALDOSE REDUCTASE INHIBITOR, IN THE TREATMENT OF DIABETIC HYPERTENSION

被引：0
|
作者：
RYDER, S [1 ]
SHAND, DG [1 ]
MULLANE, JF [1 ]
机构：
[1] AYERST LABS,NEW YORK,NY
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 1987年 / 41卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：217 / 217
页数：1
相关论文
共 50 条
  • [21] TREATMENT OF DIABETIC AUTONOMIC NEUROPATHY WITH AN ALDOSE REDUCTASE INHIBITOR
    FAES, TJC
    YFF, GA
    DEWEERDT, O
    LANTING, P
    HEIMANS, JJ
    BERTELSMANN, FW
    JOURNAL OF NEUROLOGY, 1993, 240 (03) : 156 - 160
  • [22] Correction of nerve conduction and endoneurial blood flow deficits by the aldose reductase inhibitor, tolrestat, in diabetic rats
    Cotter, MA
    Cameron, NE
    Hohman, TC
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 1998, 3 (03) : 217 - 223
  • [23] PREVENTION OF BASEMENT-MEMBRANE THICKENING IN RETINAL CAPILLARIES BY A NOVEL INHIBITOR OF ALDOSE REDUCTASE, TOLRESTAT
    ROBISON, WG
    KADOR, PF
    AKAGI, Y
    KINOSHITA, JH
    GONZALEZ, R
    DVORNIK, D
    DIABETES, 1986, 35 (03) : 295 - 299
  • [24] Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor tolrestat
    Rastelli, G
    Costantino, L
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (06) : 641 - 646
  • [25] INHIBITION OF ERYTHROCYTE ANION-EXCHANGE BY TOLRESTAT, AN INHIBITOR OF ALDOSE REDUCTASE
    GUNN, RB
    GUNN, HB
    METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (08): : 801 - 804
  • [26] EFFECT OF HYPERGLYCEMIA AND THE ALDOSE REDUCTASE INHIBITOR TOLRESTAT ON SURAL NERVE BIOCHEMISTRY AND MORPHOMETRY IN ADVANCED DIABETIC PERIPHERAL POLYNEUROPATHY
    SIMA, AAF
    GREENE, DA
    BROWN, MB
    HOHMAN, TC
    HICKS, D
    GRAEPEL, GJ
    BOCHENEK, WJ
    BEG, M
    GONEN, B
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 1993, 7 (03) : 157 - 169
  • [27] METABOLIC DISPOSITION AND PHARMACOKINETICS OF THE ALDOSE REDUCTASE INHIBITOR TOLRESTAT IN RATS, DOGS AND MONKEYS
    CAYEN, MN
    HICKS, DR
    FERDINANDI, ES
    KRAML, M
    GRESELIN, E
    DVORNIK, D
    FEDERATION PROCEEDINGS, 1984, 43 (03) : 750 - 750
  • [28] METABOLIC DISPOSITION AND PHARMACOKINETICS OF THE ALDOSE REDUCTASE INHIBITOR TOLRESTAT IN RATS, DOGS, AND MONKEYS
    CAYEN, MN
    HICKS, DR
    FERDINANDI, ES
    KRAML, M
    GRESELIN, E
    DVORNIK, D
    DRUG METABOLISM AND DISPOSITION, 1985, 13 (04) : 412 - 419
  • [29] PREVENTION OF CATARACT DEVELOPMENT IN SEVERELY GALACTOSEMIC RATS BY THE ALDOSE REDUCTASE INHIBITOR, TOLRESTAT
    SIMARDDUQUESNE, N
    GRESELIN, E
    GONZALEZ, R
    DVORNIK, D
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1985, 178 (04): : 599 - 605
  • [30] EFFICACY OF ALRESTATIN, AN ALDOSE REDUCTASE INHIBITOR, IN HUMAN DIABETIC AND NON-DIABETIC LENSES
    CHYLACK, LT
    HENRIQUES, HF
    CHENG, HM
    TUNG, WH
    OPHTHALMOLOGY, 1979, 86 (09) : 1579 - 1585
12345