EFFICIENT SYNTHESES OF 1-ARYLNAPHTHALENE LIGNAN LACTONES AND RELATED-COMPOUNDS FROM CYANOHYDRINS

被引：52

作者：

OGIKU, T ^{[1
]}

YOSHIDA, S ^{[1
]}

OHMIZU, H ^{[1
]}

IWASAKI, T ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD, APPL BIOCHEM RES LAB, OSAKA 532, JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 14期

关键词：

D O I：

10.1021/jo00119a041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Arylnaphthalene lignan lactones were synthesized in good yields from O-(tert-butyldimethylsilyl)cyanohydrins in two steps based on a conjugate addition-aldol reaction, followed by acid-catalyzed closure to form the naphthalene ring. 4-Hydroxy-1-arylnaphthalene lignan lactones were also synthesized by conjugate addition-aldol reaction, followed by aromatization-lactonization.

引用

页码：4585 / 4590

页数：6

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