Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments

被引：9
|
作者：
Enjoji, Munechika [1 ,2 ]
Kohjima, Motoyuki [3 ]
Kotoh, Kazuhiro [4 ]
Nakamuta, Makoto [2 ,3 ]
机构：
[1] Fukuoka Univ, Hlth Care Ctr, Jonan Ku, 8-19-1 Nanakuma, Fukuoka 8140180, Japan
[2] Natl Hosp Org, Kyushu Med Ctr, Clin Res Ctr, Fukuoka 8108563, Japan
[3] Natl Hosp Org, Kyushu Med Ctr, Dept Gastroenterol, Fukuoka 8108563, Japan
[4] Kyushu Univ Hosp, Dept Hepatol & Pancreatol, Fukuoka 8128582, Japan
来源：
INTERNATIONAL JOURNAL OF HEPATOLOGY | 2012年 / 2012卷
关键词：
D O I：
10.1155/2012/264017
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigations suggest that HCV infection changes the expression profile of lipid-metabolism-associated factors in the liver, conferring advantages to the life cycle of HCV. Moreover, insulin resistance and steatosis are independent predictors of impaired response to antiviral treatment in chronic hepatitis C. In this paper, we summarize our current knowledge of hepatic metabolic disorders and describe how HCV leads to and exploits these hepatic disorders. We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] Direct antiviral treatment strategies in chronic hepatitis C
    Neumann-Haefelin, C.
    Blum, H. E.
    Thimme, R.
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2012, 137 (25-26) : 1360 - 1365
  • [32] The efficacy of antiviral treatment in chronic hepatitis B patients with hepatic steatosis
    Hu, Danqing
    Wang, Peng
    Wang, Xiaojing
    Hu, Xue
    Huang, Da
    Yan, Weiming
    Xi, Dong
    Han, Meifang
    Ning, Qin
    Wang, Hongwu
    HELIYON, 2024, 10 (07)
  • [33] Metabolic abnormalities in chronic hepatitis C - Introduction
    Capeau, Jacqueline
    Gharakanian, Shahin
    Younossi, Zobair M.
    LIVER INTERNATIONAL, 2009, 29 : 1 - 2
  • [34] Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C
    Tsochatzis, E.
    Papatheodoridis, G. V.
    Manesis, E. K.
    Chrysanthos, N.
    Kafiri, G.
    Archimandritis, A. J.
    DIGESTIVE AND LIVER DISEASE, 2007, 39 (10) : 936 - 942
  • [35] Metabolic profiles in patients with chronic hepatitis C: a case–control study
    Ching-Sheng Hsu
    Chun-Jen Liu
    Chen-Hua Liu
    Chi-Ling Chen
    Ming-Yang Lai
    Pei-Jer Chen
    Ding-Shinn Chen
    Jia-Horng Kao
    Hepatology International, 2008, 2 : 250 - 257
  • [36] Prevalence of Metabolic Syndrome in Patients with Chronic Hepatitis C (CHC), Aden
    Bin Selm, Salem A.
    WORLD FAMILY MEDICINE, 2010, 8 (01): : 12 - 15
  • [37] Steatosis in chronic hepatitis C. Correlation with specific HCV genotype and metabolic co-factors
    不详
    VIRCHOWS ARCHIV, 2005, 447 (02) : 299 - 299
  • [38] Hepatic steatosis and viral hepatitis B and C: role of metabolic syndrome
    Nagy, G.
    Munteanu, M.
    Valean, S.
    Iancu, M.
    Crisan, D.
    Mircea, P.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2015, 45 : 16 - 16
  • [39] Hepatic Steatosis and Viral Hepatitis B and C: Role of Metabolic Syndrome
    Nagy, G.
    Munteanu, M.
    Chira, R.
    Valean, S.
    Crisan, D.
    Lancu, M.
    Mircea, P. A.
    PROCEEDINGS OF THE 49TH ANNUAL SCIENTIFIC MEETING OF THE EUROPEAN SOCIETY FOR CLINICAL INVESTIGATION, 2015, : 243 - 247
  • [40] Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: Evidence for a role of HCV genotype 3 in steatosis
    Castera, L
    Hezode, C
    Roudot-Thoraval, F
    Lonjon, I
    Zafrani, ES
    Pawlotsky, JM
    Dhumeaux, D
    JOURNAL OF HEPATOLOGY, 2003, 38 : 132 - 132
12345