Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension

被引：0
|
作者：
Judd, Eric [1 ]
Jaimes, Edgar A. [2 ]
机构：
[1] Univ Alabama Birmingham, Vasc Biol & Hypertens Program, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Div Nephrol, ZRB 637,1530 3rd Ave South, Birmingham, AL 35294 USA
来源：
EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2012年 / 10卷 / 03期
关键词：
aliskiren; amlodipine; angiotensin II; antihypertensive medications; cardiovascular disease; combination therapy; hypertension; renin;
D O I：
10.1586/ERC.12.7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular-related morbidity and mortality is linked to hypertension with proportional gains in cardiovascular risk factor reduction with the lowering of blood pressure. Clinical trial data has shown that attaining goal blood pressure requires, for most patients, at least two antihypertensive medications, with a significant proportion requiring regimens of three or more medications. Single-pill triple combinations have returned to the market following results of increased efficacy and adherence over dual-and mono-therapy. The combination of aliskiren, amlodipine and hydrochlorothiazide is a rational choice for combination therapy and recent studies suggest that it is safe and effective in lowering blood pressure in patients who fail dual combination therapy.
引用
收藏
页码：293 / 303
页数：11
相关论文
共 50 条
  • [31] Peripheral and Central Blood Pressure Responses of Combination Aliskiren/Hydrochlorothiazide and Amlodipine Monotherapy in African American Patients With Stage 2 Hypertension: The ATLAAST Trial
    Ferdinand, Keith C.
    Pool, James
    Weitzman, Richard
    Purkayastha, Das
    Townsend, Raymond
    JOURNAL OF CLINICAL HYPERTENSION, 2011, 13 (05): : 366 - 375
  • [32] Simultaneous determination of aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide in their triple mixture dosage form by capillary zone electrophoresis
    Salim, Mohamed M.
    Ebeid, Walid M.
    El-Enany, Nahed
    Belal, Fathalla
    Walash, Mohamed
    Patonay, Gabor
    JOURNAL OF SEPARATION SCIENCE, 2014, 37 (9-10) : 1206 - 1213
  • [33] Long-Term Efficacy and Safety of Triple-Combination Therapy With Olmesartan Medoxomil and Amlodipine Besylate and Hydrochlorothiazide for Hypertension
    Kereiakes, Dean J.
    Chrysant, Steven G.
    Izzo, Joseph L.
    Littlejohn, Thomas, III
    Oparil, Suzanne
    Melino, Michael
    Lee, James
    Fernandez, Victor
    Heyrman, Reinilde
    JOURNAL OF CLINICAL HYPERTENSION, 2012, 14 (03): : 149 - 157
  • [34] Aliskiren/Amlodipine vs. Aliskiren/Hydrochlorothiazide in Hypertension: Indirect Meta-Analysis of Trials Comparing the Two Combinations vs. Monotherapy
    Liu, Yang
    Yan, Rui
    Song, Anqi
    Niu, Xiaolin
    Cao, Chunhui
    Wei, Jin
    Dong, Xin
    Gao, Dengfeng
    AMERICAN JOURNAL OF HYPERTENSION, 2014, 27 (02) : 268 - 278
  • [35] ANTIHYPERTENSIVE EFFECTIVENESS OF AMLODIPINE IN COMBINATION WITH HYDROCHLOROTHIAZIDE
    CHRYSANT, SG
    CHRYSANT, C
    TRUS, J
    HITCHCOCK, A
    AMERICAN JOURNAL OF HYPERTENSION, 1989, 2 (07) : 537 - 541
  • [36] Aliskiren/Hydrochlorothiazide CombinationIn Mild to Moderate Hypertension
    Claudine M. Baldwin
    Greg L. Plosker
    Drugs, 2009, 69 : 833 - 841
  • [37] EFFECT OF BASELINE SYSTOLIC BLOOD PRESSURE ON RESPONSE TO TRIPLE COMBINATION AMLODIPINE/VALSARTAN/HYDROCHLOROTHIAZIDE IN PATIENTS WITH MODERATE-TO-SEVERE HYPERTENSION
    Lacourciere, Y.
    Glazer, R.
    Crikelair, N.
    Yen, J.
    Calhoun, D.
    JOURNAL OF HYPERTENSION, 2009, 27 : S119 - S119
  • [38] EFFECT OF AGE, GENDER, RACE AND ETHNICITY ON EFFICACY OF AMLODIPINE/VALSARTAN/HYDROCHLOROTHIAZIDE TRIPLE COMBINATION THERAPY IN PATIENTS WITH MODERATE TO SEVERE HYPERTENSION
    Calhoun, D.
    Glazer, R.
    Yen, J.
    Lacourciere, Y.
    JOURNAL OF HYPERTENSION, 2009, 27 : S119 - S119
  • [39] ANTIHYPERTENSIVE EFFICACY OF AMLODIPINE/VALSARTAN/HYDROCHLOROTHIAZIDE TRIPLE COMBINATION IN PATIENTS WITH OBESITY: A SUBGROUP ANALYSIS
    Calhoun, D. A.
    Lacourciere, Y.
    Crikelair, N. A.
    Yen, J.
    Glazer, R. D.
    JOURNAL OF HYPERTENSION, 2010, 28 : E575 - E575
  • [40] POPULATION PHARMACOKINETIC ANALYSIS OF HYDROCHLOROTHIAZIDE IN PATIENTS WITH HYPERTENSION FOLLOWING ADMINISTRATION OF HYDROCHLOROTHIAZIDE IN COMBINATION WITH VALSARTAN, OR AMLODIPINE, OR BOTH.
    Chen, J.
    Jiang, X.
    Parasrampuria, R.
    Sunkara, G.
    Jarugula, V.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 : S128 - S129
12345