EFFECT OF BOTHROPASE ON WOUND-HEALING

被引：0
|
作者：
UDUPA, SL [1 ]
SHAILA, HP [1 ]
UDUPA, AL [1 ]
RAMESH, KV [1 ]
KULKARNI, DR [1 ]
机构：
[1] KASTURBA MED COLL & HOSP,DEPT PHARMACOL,MANIPAL 576119,INDIA
来源：
BIOCHEMICAL ARCHIVES | 1991年 / 7卷 / 03期
关键词：
LYSYL OXIDASE; COLLAGEN; WOUND-HEALING; TENSILE STRENGTH BOTHROPASE; HEMOCOAGULANT;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of a systemic hemocoagulant, Bothropase, on wound healing process was studied in albino rats. Granuloma tissue formed on dead space wound was harvested 10 days after wounding. Tensile (breaking) strength, lysyl oxidase activity, collagen and mucopolysaccharide contents were estimated. Although tensile strength was increased significantly in the Bothropase treated animals, no significant change was observed in the lysyl oxidase activity and collagen content. However, a significant fall in mucopolysaccharide (hexuronic acid) level was observed. Increased tensile strength must therefore be attributed to mechanisms other than the formation of cross-links in collagen.
引用
收藏
页码：207 / 212
页数：6
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