FLUMECINOL, A NOVEL INDUCER OF TESTOSTERONE 16-ALPHA-HYDROXYLATION IN MALE-RATS

被引：0
|
作者：
SILVA, M
GIL, L
机构：
[1] Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago-7
来源：
XENOBIOTICA | 1990年 / 20卷 / 07期
关键词：
D O I：
10.3109/00498259009046885
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Flumecinol, a new inducer of the cytochrome P-450 monooxygenases, was studied in rats as a possible effector of liver microsomal testosterone oxidases. The drug enhanced the total content of liver cytochrome P-450 in immature and adult rats. 2. When total testosterone oxidation activity was compared in liver microsomes of treated and untreated rats, no differences in activities were observed in 60-day-old-rats, but a slight decrease was found in 35-day-old treated rats. 3. Several regio- and stereo-specific hydroxylases were modified by flumecinol administration; in 35-day-old rats only 16a-hydroxylation was induced, whereas in 60-day-old rats a slight increase in 2a-hydroxylation was also observed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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收藏
页码：689 / 697
页数：9
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