SUBSTRATE-SPECIFICITY OF ESCHERICHIA-COLI THYMIDINE PHOSPHORYLASE FOR PYRIMIDINE NUCLEOSIDES WITH ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY

被引：15

作者：

SCHINAZI, RF

PECK, A

SOMMADOSSI, JP

机构：

[1] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

[2] UNIV ALABAMA,DEPT PHARMACOL,DIV CLIN PHARMACOL,CTR AIDS RES,BIRMINGHAM,AL 35294

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 02期

关键词：

D O I：

10.1016/0006-2952(92)90001-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Various nucleoside antiviral agents and their metabolites were examined for their ability to be cleaved across the glycosidic bond by Escherichia coli thymidine phosphorylase. The increasing order of susceptibility to cleavage was U > T >> C derivatives. Nucleosides that were unsaturated in the sugar moiety were more susceptible than saturated ones. 3'-Deoxy-2',3'-didehydrothymidine was a substrate, whereas 3'-azido-, 3'-fluoro-, 3'-oxo- and 3'-thiapyrimidine nucleosides were resistant to this enzyme.

引用

页码：199 / 204

页数：6

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