INVITRO EFFECT OF SYNTHETIC FLAVANOIDS ON ASTROVIRUS INFECTION

被引：14
|
作者：
SUPERTI, F
SEGANTI, L
ORSI, N
DESIDERI, N
STEIN, ML
TINARI, A
MARZIANO, ML
DONELLI, G
机构：
[1] UNIV ROME LA SAPIENZA,FAC MED,IST MICROBIOL,I-00185 ROME,ITALY
[2] UNIV ROME LA SAPIENZA,FAC FARM,DIPARTIMENTO STUDI FARMACEUT,I-00185 ROME,ITALY
来源：
ANTIVIRAL RESEARCH | 1990年 / 13卷 / 04期
关键词：
Astrovirus; Synthetic flavanoid;
D O I：
10.1016/0166-3542(90)90038-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study we investigated the activity of halogeno-, cyano- and amidino-isoflavenes, isoflavans and flavans on the multiplication of human astroviruses. These are naked small round viruses which have been recognized as causative agents of human gastroenteritis, and whose capsid proteins are similar to those of picornaviruses. Although all drugs tested caused a dose-dependent reduction of viral antigen synthesis as monitored by immunofluorescence, the chloro derivatives were the most effective. © 1990.
引用
收藏
页码：201 / 208
页数：8
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