AMPLIFICATION AND OVEREXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR GENE IN HUMAN RENAL-CELL CARCINOMA

被引：77

作者：

ISHIKAWA, J

MAEDA, S

UMEZU, K

SUGIYAMA, T

KAMIDONO, S

机构：

[1] KOBE UNIV,SCH MED,DEPT PATHOL,7-5-1 KUSUNOKI CHO,CHUO KU,KOBE 650,JAPAN

[2] KOBE NATL HOSP,DEPT UROL,SUMA KU,KOBE 65401,JAPAN

[3] KYOTO UNIV,FAC MED,DEPT PATHOL,SAKYO KU,KYOTO 606,JAPAN

[4] KOBE UNIV,SCH MED,DEPT UROL,KOBE 650,JAPAN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 06期

关键词：

D O I：

10.1002/ijc.2910450606

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined 22 cases of renal‐cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (EGFR) gene and found gene amplification in one case of high‐stage‐high‐grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression of the EGFR gene in 12 of 20 (60%) cases of RCC. The highest expression was observed in the geneamplified case. No correlation was observed between the level of EGFR mRNA and tumor stage or grade. Northern blot analysis revealed normal 10‐ and 5.6‐kb EGFR mRNA bands in RCC. Our data indicate that gene amplification of the EGFR gene is one of the molecular mechanisms of its overexpression in a subset of RCCs. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1018 / 1021

页数：4

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