LACK OF EFFECT OF CHRONIC DOPAMINE RECEPTOR BLOCKADE ON D2 DOPAMINE RECEPTOR MESSENGER-RNA LEVEL

被引：98
|
作者：
VANTOL, HHM
RIVA, M
CIVELLI, O
CREESE, I
机构：
[1] RUTGERS STATE UNIV, CTR MOLEC & BEHAV NEUROSCI, 195 UNIV AVE, NEWARK, NJ 07102 USA
[2] OREGON HLTH SCI UNIV, VOLLUM INST ADV BIOMED RES, PORTLAND, OR 97201 USA
来源：
NEUROSCIENCE LETTERS | 1990年 / 111卷 / 03期
关键词：
Antipsychotic drug; Clozapine; D[!sub]1[!/sub] dopamine receptor; D[!sub]2[!/sub] dopamine receptor mRNA; Haloperidol; Raclopride; SCH23390;
D O I：
10.1016/0304-3940(90)90279-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The chronic treatment of rats with antipsychotic drugs which increase striatal D2 dopamine receptors did not measurably increase the level of D2 receptor mRNA indicating that the observed increase in receptors was not primarily due to transcriptional regulation. These and other data suggest that the molecular mechanisms involved in receptor regulation in response to denervation or neurotransmitter depletion may be different from those which occur in response to chronic receptor blockade by antagonist drugs. © 1990.
引用
收藏
页码：303 / 308
页数：6
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