THE ROLE OF COMPLEMENT-DERIVED CHEMOTACTIC FACTORS IN LUNG INJURY-INDUCED BY PREFORMED IMMUNE-COMPLEXES

被引：7
|
作者：
TANOUE, M
YOSHIZAWA, Y
SATO, T
YANO, H
KIMULA, Y
MIYAMOTO, K
机构：
[1] UNIV TSUKUBA,INST CLIN MED,DIV PULM MED,TSUKUBA,IBARAKI 305,JAPAN
[2] YOKOHAMA RED CROSS HOSP,DEPT INTERNAL MED,YOKOHAMA,JAPAN
[3] YOKOSUKA KYOSAI HOSP,DEPT PATHOL,YOKOSUKA,JAPAN
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1993年 / 101卷 / 01期
关键词：
IMMUNE COMPLEX; LUNG INJURY; CHEMOTACTIC FACTOR; COMPLEMENT-DERIVED;
D O I：
10.1159/000236497
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Our previous studies have suggested a role for complement fragments presumably activated by immune complexes in patients with hypersensitivity pneumonitis. The present study has shown that circulating complement depletion by cobra venom factor resulted in the reduction in severity of immune-complex-mediated pulmonary inflammation. The activity of chemotactic factors for neutrophils generated in bronchoalveolar lavage fluids in complement-depleted animals was significantly diminished to 61.2% compared to the undepleted animals. In addition, reduced activitv of chemotactic factors resulted in a marked reduction of accumulation of neutrophils in bronchoalveolar lavage fluids indicating that chemotactic factors play an important role in the sequestration of neutrophils on the alveolar side of the lung. In conclusion, chemotactic factors in bronchoalveolar lavage fluids which preceded the accumulation of polymorphonuclear cells are partially derived from complement.
引用
收藏
页码：47 / 51
页数：5
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