IN-VITRO GAMETOCYTOCIDAL ACTIVITY OF ARTEMISININ AND ITS DERIVATIVES ON PLASMODIUM-FALCIPARUM

被引：26
|
作者：
MEHRA, N
BHASIN, VK
机构：
[1] Department of Zoology, University of Delhi
来源：
JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY | 1993年 / 46卷 / 01期
关键词：
D O I：
10.7883/yoken1952.46.37
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Artemisinin and six of its derivatives were evaluated for their in vitro gametocytocidal and erythrocytic schizontocidal properties on an Indian isolate of Plasmodium falciparum. One of the metabolic derivatives, DADF-dihydroartemisinin (NIH02), was found to possess gametocytocidal and erythrocytic schizontocidal properties similar to those of artemisinin. Gametocytes of this isolate were highly susceptible to the toxic effect of NIH02 (IC50=6.6 ng/ml) and younger stages were more sensitive. This is the first report about the in vitro game to cytocidal properties of a derivative of artemisinin.
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页码：37 / 43
页数：7
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