SYNTHESIS AND EXCITATORY AMINO-ACID PHARMACOLOGY OF SOME NOVEL QUINOXALINEDIONES

被引：28
|
作者：
EPPERSON, JR
HEWAWASAM, P
MEANWELL, NA
BOISSARD, CG
GRIBKOFF, VK
POSTMUNSON, D
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80768-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and amino acid pharmacology of twelve N-substituted quinoxalinediones is reported. In particular, compounds 4a and 4b show significant antagonism at both the AMPA and glycine-site NMDA receptors. The functional antagonism of 4a has been demonstrated.
引用
收藏
页码：2801 / 2804
页数：4
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