THE ONE-STEP SYNTHESIS OF CHIRAL AMINO PHOSPHINO FERROCENES

Reaction of the chiral lithium reagent-2-lithio-(alpha-N,N-dimethyl)aminoethylbenzene with 1,1'-ferrocenediylphenylphosphine gives chiral aminophosphinoferrocenes that contain both chiral carbon and phosphorus centres. Treatment of the ferroceno-phane with 2-lithio-N,N-dimethylaminomethylferrocene followed by hydrolysis gives the product ferrocenyl 2-(dimethylaminomethylferrocenyl) phenylphosphine as a pair of diastereomers. The single crystal structures of compound 3a PdCl2 and compound 4. PdCl2.2CH(2)Cl(2) have been determined. The compounds, 2-(ferrocenylphenylphosphino)-1-(alpha-N, N'-dimethylaminoethylbenzene)ferrocene, 5 and 1-[2-(alpha-N,N'-dimethyraminoethylbenzene)phenylphospphino]-1'-diphenylphosphinoferrocene, 6a, have also been prepared by minor modifications of the methodology developed.