MOTOR-NEURON DISEASE AND EXPOSURE TO CHEMICALS - ETIOLOGIC SUGGESTIONS FROM A CASE-CONTROL STUDY

被引：6

作者：

GUNNARSSON, LG

机构：

[1] Department of Neurology, Örebro Medical Center Hospital

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 124卷

关键词：

EPIDEMIOLOGY; AMYOTROPHIC LATERAL SCLEROSIS; ENVIRONMENT; HEREDITY; SOLVENTS;

D O I：

10.1016/0022-510X(94)90180-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A recent case-control study indicates that some males are genetically predisposed to develop motor neuron disease if they are exposed to chemicals, particularly solvents. Markets for such a predisposition are hereditary for a neurodegenerative disease and/or a thyroid disease. The reason for this susceptibility might be pharmacogenetic polymorphism, which causes deficient detoxification entailing oxidative stress and cell death.

引用

页码：62 / 63

页数：2

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