REPEATABLE ESTIMATION OF THE GLOMERULAR-FILTRATION RATE (GFR) AND OF THE EFFECTIVE RENAL PLASMA-FLOW (ERPF) ON CONSCIOUS RATS BY MEANS OF INULIN AND PARA-AMINOHIPPURIC ACID

Estimation of the glomerular filtration rate (GFR) and of the effective renal plasma flow (ERPF) by means of the test substances inulin and p-aminohippuric acid according to the steady state clearance measurement during the drop of the plasma level after the initially injection of an depot of the indicators was examined methodologically. The procedure should be repeatable in the same animal under conscious conditions. The results demonstrate that the described method is adaquate with regard to accuracy, reproducibility and sensitivity for the estimation of the GFR, whereas limitations apply to calculation of the ERPF.