EFFECTS OF ESTAZOLAM AND TRIAZOLAM ON TRANSIENT INSOMNIA ASSOCIATED WITH PHASE-SHIFTED SLEEP

被引：16

作者：

SCHWEITZER, PK

KOSHOREK, G

MUEHLBACH, MJ

MORRIS, DD

ROEHRS, T

WALSH, JK

ROTH, T

机构：

[1] ABBOTT LABS,ABBOTT PK,IL

[2] HENRY FORD HOSP,CTR SLEEP DISORDERS & RES,DETROIT,MI 48202

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1991年 / 6卷 / 02期

关键词：

TRANSIENT INSOMNIA; PHASE-SHIFTED SLEEP; BENZODIAZEPINES; ESTAZOLAM; TRIAZOLAM; PERFORMANCE; MSLT; CIRCADIAN RHYTHMS;

D O I：

10.1002/hup.470060204

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Forty-eight healthy volunteers with a normal sleep/wake history participated in a two-centre, double-blind, parallel group study comparing the effects of estazolam 2.0 mg, triazolam 0.25 mg, and placebo on sleep, performance and alertness following 180 degree reversal in sleep/wake schedule. Sleep-phase reversal produced decreased sleep time, primarily during the last 2 hours of the sleep period. Estazolam prevented this transient insomnia by maintaining sleep in the latter part of the sleep period. Triazolam did not significantly change total sleep time, which was intermediate between that of the estazolam and placebo groups. Neither active compound produced significant effects on subsequent performance or alertness.

引用

页码：99 / 107

页数：9

共 39 条

[31] A Randomized, Double-Blind, Single-Dose, Placebo-Controlled, Multicenter, Polysomnographic Study of Gabapentin in Transient Insomnia Induced by Sleep Phase Advance
Rosenberg, Russell P.
Hull, Steven G.
Lankford, D. Alan
Mayleben, David W.
Seiden, David J.
Furey, Sandy A.
Jayawardena, Shyamalie
Roth, Thomas
JOURNAL OF CLINICAL SLEEP MEDICINE, 2014, 10 (10): : 1093 - 1100
[32] A Randomized, Double-Blind, Placebo-Controlled, Multicenter, 28-Day, Polysomnographic Study of Gabapentin in Transient Insomnia Induced by Sleep Phase Advance
Furey, Sandy A.
Hull, Steven G.
Leibowitz, Mark T.
Jayawardena, Shyamalie
Roth, Thomas
JOURNAL OF CLINICAL SLEEP MEDICINE, 2014, 10 (10): : 1101 - 1109
[33] Are cognitive "insomnia" processes involved in the development and maintenance of Delayed Sleep-Wake Phase Disorder? Treatment effects and comparisons with good sleepers
Richardson, C.
Cain, N.
Bartel, K.
Gradisar, M.
JOURNAL OF SLEEP RESEARCH, 2016, 25 : 111 - 112
[34] CHANGES OF COGNITIVE AND BEHAVIORAL FACTORS AND AROUSAL LEVEL ASSOCIATED WITH TREATMENT EFFECTS OF CBT-I IN INSOMNIA WITH SHORT AND LONGER OBJECTIVE SLEEP DURATION
Yang, C. -M.
Huang, Y. -C.
Jan, Y. -W.
Lee, X. -C.
SLEEP MEDICINE, 2019, 64 : S429 - S429
[35] CAN AN INSOMNIA THERAPY TREAT SLEEP MAINTENANCE WITHOUT SUPPRESSING AROUSABILITY: EFFECTS; OF DOXEPIN 1, 3, AND 6 MG ACROSS PHASE 3 TRIALS
Durrence, H.
Jochelson, P.
Rogowski, R.
SLEEP, 2009, 32 : A255 - A255
[36] EFFECTS OF DOPAMINERGIC BLOCKADE ON THE SLEEP-ASSOCIATED CHANGES OF LUTEINIZING-HORMONE PULSATILITY IN EARLY FOLLICULAR PHASE WOMEN
ROSSMANITH, WG
MORTOLA, JF
YEN, SSC
NEUROENDOCRINOLOGY, 1988, 48 (06) : 634 - 639
[37] Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study
Makoto Uchiyama
Daiji Kambe
Yumiko Imadera
Yu Kajiyama
Hiroki Ogo
Naohisa Uchimura
Psychopharmacology, 2022, 239 : 2143 - 2154
[38] Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study
Uchiyama, Makoto
Kambe, Daiji
Imadera, Yumiko
Kajiyama, Yu
Ogo, Hiroki
Uchimura, Naohisa
PSYCHOPHARMACOLOGY, 2022, 239 (07) : 2143 - 2154
[39] THE EFFECTS OF DARIDOREXANT 50 MG ON PATIENTS WITH COMORBID INSOMNIA DISORDER AND UNTREATED MILD OBSTRUCTIVE SLEEP APNEA: A SUBGROUP POST-HOC ANALYSIS OF A PHASE 3 CLINICAL TRIAL
Lettieri, C. J.
Leger, D.
Luyet, P. P.
Malhotra, A.
Pepin, J. -L.
Quan, S. F.
Saskin, P.
Briasoulis, O.
SLEEP MEDICINE, 2024, 115 : 392 - 393

← 1 2 3 4 →