HORMONAL RESPONSES TO SHORT-TERM FASTING IN POSTMENOPAUSAL WOMEN

被引:41
|
作者
BEITINS, IZ
BARKAN, A
KLIBANSKI, A
KYUNG, N
REPPERT, SM
BADGER, TM
VELDHUIS, J
MCARTHUR, JW
机构
[1] MASSACHUSETTS GEN HOSP, DEPT PEDIAT, VINCENT RES LABS, BOSTON, MA 02114 USA
[2] MASSACHUSETTS GEN HOSP, DEPT GYNECOL, VINCENT RES LABS, BOSTON, MA 02114 USA
[3] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[4] UNIV MICHIGAN, DEPT MED, ANN ARBOR, MI 48109 USA
[5] UNIV VIRGINIA, DEPT MED, CHARLOTTESVILLE, VA 22908 USA
来源
关键词
D O I
10.1210/jcem-60-6-1120
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Urinary excretion of gonadotropins increases during fasting. Whether this increase results from increased pituitary secretion of LH [luteinizing hormone] and FSH or from altered renal excretion of protein molecules was investigated. To this end, urinary gonadotropin excretion, serum gonadotropin levels and pituitary responsiveness of LHRH were studied during control, 10 day fasting, and refeeding periods in 10 mildly obese postmenopausal women. Additionally, urinary cortisol and estriol excretion and circulating levels of dehydroepiandrosterone sulfate, estradiol, estrone, melatonin, norepinephrine, epinephrine and dopamine was measured during the control, fasting and refeeding periods. While urinary excretion of gonadotropins increased markedly during fasting, there were no significant changes in serum gonadotropin levels or in the pituitary sensitivity to LHRH. Plasma norepinephrine and serum melatonin increased significantly during fasting, but serum and urinary estrogens, indices of adrenal activity, and plasma levels of epinephrine and dopamine did not change. Apparently, the stress of short-term fasting selectively activates only certain components of the neuroendocrine system without any appreciable changes in the function of the gonadotropin-secreting system. Fasting-induced gonadotropinuria is probably explained by altered renal handling of gonadotropin molecules.
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收藏
页码:1120 / 1126
页数:7
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