IN VIVO CHARACTERISATION OF 3-IODO-6-METHOXYBENZAMIDE I-123 IN HUMANS

被引：83
|
作者：
COSTA, DC
VERHOEFF, NPLG
CULLUM, ID
ELL, PJ
SYED, GMS
BARRETT, J
PALAZIDOU, E
TOONE, B
VANROYEN, E
BOBELDIJK, M
机构：
[1] UNIV AMSTERDAM, AMSTERDAM, NETHERLANDS
[2] UNIV LONDON KINGS COLL HOSP, LONDON SE5 8RX, ENGLAND
[3] CYGNE BV, EINDHOVEN, NETHERLANDS
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 11期
关键词：
!sup]123[!/sup]I-IBZM; Dopamine D2; Dynamic SPET; Schizophrenia;
D O I：
10.1007/BF00833017
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
3-Iodo-6-methoxybenzamide (123I-IBZM), a new Dopamine D2 receptor ligand, was used in conjunction with SME 810 brain tomography to study six subjects (one normal volunteer, four schizophrenics and one DAT patient). Initial Dynamic SPET was followed by multislice SPET. High-resolution images of the D2 receptor distribution in the basal ganglia were obtained. The specific binding in D2 receptors of the basal ganglia is highest from 2-4 h p.i. Patients on anti-psychotic drugs showed significantly lower specific binding. Dopamine D2 brain receptor availability in man may now be studied with SPET. Continuous data acquisition with single slice tomography is particularly important in the study of this type of radiotracers. © 1990 Springer-Verlag.
引用
收藏
页码：813 / 816
页数：4
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