KIT PREPARATION OF N.C.A. 3-[I-123]IODO-L-ALPHA-METHYLTYROSINE [I-123] IMT, 3-[I-123]IODO-O-METHYL-L-TYROSINE [I-123] OMIT AND 3-[I-123]IODO-O-METHYL-L-ALPHA-METHYLTYROSINE[I-123]OMIMT USING SEP-PAKTM C-18

A kit preparation for three radioiodinated L-tyrosine derivatives avoiding HPLC purification is described. Using Iodo-gen(TM) as an oxidant either in aqueous or in organic media, followed by simple solid phase extraction, yields 85 +/- 5% n.c.a. [I-123]IMT, 50 +/- 5% n.c.a. [I-123]OMIT and n.c.a. [I-123]OMIMT with radiochemical purities > 98% in less than 40 and 90 min, respectively.