BUILDING-BLOCKS FOR GLYCOPEPTIDE SYNTHESIS - GLYCOSYLATION OF 3-MERCAPTOPROPIONIC ACID AND FMOC AMINO-ACIDS WITH UNPROTECTED CARBOXYL GROUPS

被引：89

作者：

ELOFSSON, M ^{[1
]}

WALSE, B ^{[1
]}

KIHLBERG, J ^{[1
]}

机构：

[1] LUND INST TECHNOL,CTR CHEM,POB 124,S-22100 LUND,SWEDEN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 51期

关键词：

GLYCOSYLATED AMINO ACID; LEWIS ACID; MINIMAL PROTECTION; PERACETYLATED GLYCOSYL DONOR; GLYCOPEPTIDE;

D O I：

10.1016/0040-4039(91)80548-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Mercaptopropionic acid and Fmoc amino acids, having unprotected carboxyl groups, were glycosylated with sugar 1,2-trans-acetates in 90 and 53-65% yields, respectively, under Lewis acid promotion. The synthesis of a neoglycopeptide illustrates the use of the building blocks in solid phase peptide synthesis.

引用

页码：7613 / 7616

页数：4

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