SIGNIFICANCE OF EMPTY LIPOSOMES ALONE AND AS DRUG CARRIERS IN DERMATOTHERAPY

被引：0
|
作者：
GEHRING, W [1 ]
GHYCZY, M [1 ]
GLOOR, M [1 ]
HEITZLER, C [1 ]
RODING, J [1 ]
机构：
[1] NATTERMANN PHOSPHOLIPID GMBH,COLOGNE,GERMANY
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1990年 / 40-2卷 / 12期
关键词：
BETAMETHASONE VALERATE; CLINICAL STUDIES; DRUG CARRIERS; LIPOSOMES; VASCULAR EFFECTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The influence of three different liposome formulations (NAT 106, NAT 50, NAT 89), as empty liposomes and loaded with 0.05 % betamethasone, on blood circulation in the corium was investigated by means of laser Doppler flowmetry. All three empty liposomes brought about a decrease in circulation. The maximum effect was reached 90 min after a 30-min occlusive application of the test preparations. Loading with betamethasone resulted in a significant increase in circulation after only 15 min. This increase in interpreted as a steroid effect. No comparable symptoms appeared with the application of base cream DAC (an O/W emulsion) or of betamethasone in base cream under identical experimental conditions.
引用
收藏
页码：1368 / 1371
页数：4
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