SIGNIFICANCE OF EMPTY LIPOSOMES ALONE AND AS DRUG CARRIERS IN DERMATOTHERAPY

被引：0

作者：

GEHRING, W ^{[1
]}

GHYCZY, M ^{[1
]}

GLOOR, M ^{[1
]}

HEITZLER, C ^{[1
]}

RODING, J ^{[1
]}

机构：

[1] NATTERMANN PHOSPHOLIPID GMBH,COLOGNE,GERMANY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1990年 / 40-2卷 / 12期

关键词：

BETAMETHASONE VALERATE; CLINICAL STUDIES; DRUG CARRIERS; LIPOSOMES; VASCULAR EFFECTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of three different liposome formulations (NAT 106, NAT 50, NAT 89), as empty liposomes and loaded with 0.05 % betamethasone, on blood circulation in the corium was investigated by means of laser Doppler flowmetry. All three empty liposomes brought about a decrease in circulation. The maximum effect was reached 90 min after a 30-min occlusive application of the test preparations. Loading with betamethasone resulted in a significant increase in circulation after only 15 min. This increase in interpreted as a steroid effect. No comparable symptoms appeared with the application of base cream DAC (an O/W emulsion) or of betamethasone in base cream under identical experimental conditions.

引用

页码：1368 / 1371

页数：4

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