EFFECTS OF ANTIARRHYTHMIC AGENTS CLASSIFIED AS CLASS-III GROUP ON ISCHEMIA-INDUCED MYOCARDIAL DAMAGE IN CANINE HEARTS

被引：15
|
作者：
SANO, T
SUGIYAMA, S
TAKI, K
HANAKI, Y
SHIMADA, Y
OZAWA, T
机构：
[1] NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NAGOYA UNIV,FAC MED,DEPT ANESTHESIOL,NAGOYA,AICHI 466,JAPAN
[3] NAGOYA UNIV,FAC MED,DEPT INTERNAL MED,NAGOYA,AICHI 466,JAPAN
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 99卷 / 03期
关键词：
D O I：
10.1111/j.1476-5381.1990.tb12971.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The cardioprotective effects of antiarrhythmic agents classified as class III, amiodarone, sotalol and E-4031, were investigated in anaesthetized dogs. The left anterior descending coronary artery was occluded for 2 h. Heart mitochondria were prepared from both the ischaemic and non-ischaemic areas, and their function was estimated polarographically. Activities of the lysosomal enzymes, N-acetyl-β-glucosaminidase and β-glucuronidase, were measured in each fraction. Two hour occlusion induced ventricular arrhythmias, and amiodarone, sotalol and E-4031 greatly suppressed the development of arrhythmias. Amiodarone, sotalol and E-4031 significantly protected mitochondria against ischaemia, and prevented ischaemia-induced leakage of lysosomal enzymes. Antiarrhythmic agents classified as class III show cardioprotective effects, which might participate in their antiarrhythmic effect.
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页码：577 / 581
页数：5
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