Cutaneous Squamous Cell Carcinoma Developing from Recessive Dystrophic Epidermolysis Bullosa: A Case Report and an Immunohistochemical Study

被引：5

作者：

Tsukada, Akira ^{[1
]}

Fujimura, Taku ^{[1
]}

Furudate, Sadanori ^{[1
]}

Kambayashi, Yumi ^{[1
]}

Numata, Yukikazu ^{[1
]}

Haga, Takahiro ^{[1
]}

Hashimoto, Akira ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan

来源：

CASE REPORTS IN DERMATOLOGY | 2012年 / 4卷 / 03期

关键词：

Recessive dystrophic epidermolysis bullosa; Squamous cell carcinoma; Immunosuppressive cells; Carcinogenesis;

D O I：

10.1159/000343082

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We describe a 49-year-old Japanese woman with cutaneous squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa (RDEB). Interestingly, immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages and numerous Foxp3(+) regulatory T cells (Tregs) around the tumor. Since the contribution of immunosuppressive factors (e.g. TGF beta) to the carcinogenesis of SCC from RDEB was recently reported, our present findings suggest one of the possible contributions of immunosuppressive cells, such as CD163(+) M2 macrophages and Tregs, to the carcinogenesis of SCC from RDEB.

引用

页码：197 / 201

页数：5

共 50 条

[31] Cemiplimab treatment of squamous cell carcinoma in a patient with severe recessive dystrophic epidermolysis bullosa
Vasilev, Preslav
Kalev, Dimitar
Karamanliev, Martin
Dimitrov, Dobromir
Troyanova, Petranka
Yordanova, Ivelina
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2023, 21 (03): : 295 - 297
[32] SQUAMOUS-CELL CARCINOMA SECONDARY TO RECESSIVE DYSTROPHIC EPIDERMOLYSIS-BULLOSA - A REPORT OF 4 PATIENTS WITH 17 PRIMARY CUTANEOUS MALIGNANCIES
NEWMAN, C
WAGNER, RF
TYRING, SK
SPIGEL, GT
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1992, 18 (04): : 301 - 305
[33] A CASE OF RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA
KOCABAY, K
GUVENC, H
OKTEN, A
BEKTAS, S
TURKISH JOURNAL OF PEDIATRICS, 1988, 30 (03) : 187 - 191
[34] Pembrolizumab for Treatment of a Patient With Multiple Cutaneous Squamous Cell Carcinomas and Recessive Dystrophic Epidermolysis Bullosa
Piccerillo, Alfredo
El Hachem, Maya
De Vito, Rita
De Luca, Erika Valentina
Peris, Ketty
JAMA DERMATOLOGY, 2020, 156 (06) : 708 - 710
[35] Accelerated Aging and Microsatellite Instability in Recessive Dystrophic Epidermolysis Bullosa-Associated- Associated Cutaneous Squamous Cell Carcinoma
Lee, Catherine A. A.
Wu, Siyuan
Chow, Yuen Ting
Kofman, Eric
Williams, Valencia
Riddle, Megan
Eide, Cindy
Ebens, Christen L.
Frank, Markus H.
Tolar, Jakub
Hook, Kristen P.
Aldubayan, Saud H.
Frank, Natasha Y.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2024, 144 (07) : 1534 - 1543.e2
[36] Expression of matrilysin-1 (MMP-7) in cutaneous squamous cell carcinoma in recessive dystrophic epidermolysis bullosa
Kivisaari, A
McGrath, JA
Bauer, JW
Konigova, R
Sawamura, D
Sato-Matsumura, KC
Kähäri, M
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (02)
[37] Squamous cell carcinoma in junctional and dystrophic epidermolysis bullosa
Weber, F
Bauer, JW
Sepp, N
Högler, W
Salmhofer, W
Hintner, H
Fritsch, P
ACTA DERMATO-VENEREOLOGICA, 2001, 81 (03) : 189 - 192
[38] Squamous cell carcinoma complicating recessive dystrophic epidermolysis bullosa-Hallopeau-Siemens: a report of four cases
Dammak, Anis
Zribi, Jihen
Boudaya, Sonia
Meziou, Taha Jalel
Masmoudi, Abderrahmen
Ellouze, Zoubair
Keskes, Hassib
Turki, Hamida
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2009, 48 (06) : 588 - 591
[39] Recessive dystrophic epidermolysis bullosa.: Report of one case
Cordero, C
González, S
Castillo, C
Morales, E
Misad, C
Ruiz-Esquide, F
REVISTA MEDICA DE CHILE, 2004, 132 (05) : 614 - 618
[40] RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA AND MULTIPLE SQUAMOUS-CELL CARCINOMAS
CARAPETO, FJ
PASTOR, JA
MARTIN, J
AGURRUZA, J
DERMATOLOGICA, 1982, 165 (01): : 39 - 46

← 1 2 3 4 5 →